MicroRNA-214 promotes chronic kidney disease by disrupting mitochondrial oxidative phosphorylation

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Local lymph node recurrence after central neck dissection in papillary thyroid cancers: A meta analysis

BackgroundProphylactic central neck dissection (CND) at the time of total thyroidectomy (TT) remains controversial in clinically node-negative (cN0) papillary thyroid carcinoma (PTC). This systematic review and meta-analysis was performed to compare the local recurrence between patients who underwent TT plus CND and those who underwent TT alone.MethodsThe publicly available literature published from January 1990 to October 2017 concerning TT plus prophylactic CND versus TT for PTC was retrieved by searching the national and international online databases. Meta-analysis was performed after the data extraction process.ResultsTwenty-five studies with comparison between TT + CND and TT alone were eligible and included in this meta-analysis. For both PTC and papillary thyroid microcarcinoma (PTMC), the overall recurrence in TT + CND group was significantly lower than that in TT alone group. The central compartment recurrence was significantly higher in TT alone group than TT + CND group (OR = 3.41, 95% Cl [2.00 ～ 5.80], P < 0.00001), while no significant difference of lateral compartment recurrence was observed between the two groups (OR = 1.19, 95%Cl [0.81 ～ 1.77], P = 0.38). We compared ipsilateral CND + TT with TT alone and found that the recurrence was not significantly different between the two groups (OR = 1.44, 95%Cl [0.74 ～ 2.81], P = 0.28). On the other hand, bilateral CND + TT showed significantly low recurrence (OR = 2.48, 95%Cl [1.75 ～ 3.53], P < 0.00001).ConclusionsThe addition of CND to TT resulted in a greater reduction in risk of local recurrence than TT alone, especially preventing central neck recurrences. Additionally, we discovered that bilateral CND in patients with PTC > 1 cm was necessary.     

建设世界一流科技期刊的策略——基于Nature、Science、The Lancet和Cell的分析

【目的】 探索建设世界一流科技期刊的策略,以助力中国科技期刊冲刺世界一流水平。【方法】 通过研读相关政策和研究文献,结合对Nature、Science、The Lancet、Cell等不同类型的世界一流科技期刊的分析,解析世界一流科技期刊的概念及内涵,探讨建设世界一流科技期刊的充分条件和必要条件,提出建设世界一流科技期刊的建议。【结果】 卓越的办刊理念、全方位的国际化水平、世界一流的人才队伍、先进的经营管理水平以及汇聚一流前沿成果、卓著的科学声望是建设世界一流科技期刊的必要条件。“高、精、尖”和“稳、准、狠”的办刊策略,是建设世界一流科技期刊的充分条件。建设世界一流科技期刊要理性且准确地认知其内涵,始终坚持卓越的办刊理念、国际化战略、人才战略、质量战略和集群化战略。【结论】 中国科技期刊既要扎根祖国大地,又要学习世界一流期刊的成功经验,从办刊的硬实力和软实力方面吸收借鉴,才能探索出具有中国特色的世界一流科技期刊建设路径。     

COVID-19: A tale of two pandemics across the Asia Pacific region

The widely diverse impacts of SAR-CoV-2 infection resulting in the COVID-19 pandemic cannot be held in more stark relief when contrasting the devastating impact upon China, Italy, Great Britain, America and Brazil with the considerably milder course in the geographically isolated countries of Australia and New Zealand and the densely populated Vietnam. Children in the Asia-Pacific region, as with children all over the world to date, have fared better than older adults. Other countries in the Asia-Pacific region, including Indonesia and India have struggled to deal with the pandemic because of a lack of health infrastructure, inability to provide sufficient testing and isolation and widespread poverty. This article will provide a snapshot of the impact of COVID-19 upon countries in the Asia-Pacific region in the six months since the first case of the novel zoonotic coronavirus infection appeared in China.     

中国X连锁视网膜色素变性家系RPGR新突变

目的 检测分析被诊断为X连锁视网膜色素变性（XLRP）的三个中国家系内的基因突变。设计 基因研究。研究对象 三个中国XLRP家系共27位受试者（其中18人为男性）。方法 由同一医生收集家系成员的详细临床资料并进行眼部检查，采集三个家系的先证者及有条件采血者的外周静脉血，提取基因组DNA。应用PCR技术扩增RPGR和RP2基因的全部外显子和内含子交界区序列，包括RPGR基因15号外显子开放阅读框，产物直接测序进行突变分析。主要指标 临床特征及基因测序结果。结果 基因筛查证实了两个RPGR基因的新型无义突变(c.1541C>G;p.S514X 和 c.2833G>T;p.E945X) 及一个错义突变(c.607G>C;p.A203P)。基因型-表型的相关性分析表明家系3患者在接近ORF15下游位置存在突变，这种突变导致视锥细胞功能的早期丧失。ORF15无义突变的女性携带者临床表型重，呈现出部分显性遗传的特点。结论 本研究证实了三种RPGR基因的新型突变，这一结果扩展了RPGR的突变谱及表型谱。     

中国台湾地区缩减数位落差政策及其启示

世界各地均在加速推进教育信息化建设，但快速的 e 化发展，会因民众自身条件的不同造成不均的现象，并导致阶层、地域及群体间的“数位落差”。数位落差是世界各地政府在推动信息化的过程中都无法避免的，大陆地区也不例外。由于中国台湾地区具有与大陆相似的文化氛围和相近的教育发展历史，该文通过梳理和解读中国台湾地区现有的缩减数位落差政策，以期为大陆地区研制专门化政策来应对当前挑战，推进教育信息化的均衡发展提供借鉴。